Analytical Data
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基因名
PTF1a
- Application
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别名
PTF1a；BHLHA29；PTF1P48；Pancreas transcription factor 1 subunit alpha
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7RTS3
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表达区间
1-328aa
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氨基酸序列
MDAVLLEHFP GGLDAFPSSY FDEDDFFTDQ SSRDPLEDGD ELLADEQAEV EFLSHQLHEY CYRDGACLLL QPAPPAAPLA LAPPSSGGLG EPDDGGGGGY CCETGAPPGG FPYSPGSPPS CLAYPCAGAA VLSPGARLRG LSGAAAAAAR RRRRVRSEAE LQQLRQAANV RERRRMQSIN DAFEGLRSHI PTLPYEKRLS KVDTLRLAIG YINFLSELVQ ADLPLRGGGA GGCGGPGGGG RLGGDSPGSQ AQKVIICHRG TRSPSPSDPD YGLPPLAGHS LSWTDEKQLK EQNIIRTAKV WTPEDPRKLN SKSSFNNIEN EPPFEFVS
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分子量
34.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTF1a, or Pancreas-Associated Transcription Factor 1a, is a crucial transcription factor involved in the development and function of the pancreas and its associated tissues. It belongs to the basic helix-loop-helix (bHLH) family of proteins and plays a pivotal role in initiating and maintaining the pancreatic progenitor state during embryonic development. Researchers have identified that PTF1a is essential for the differentiation of pancreatic exocrine cells and the regulation of insulin-producing β-cells, making it a vital component in understanding pancreatic development and function. Given its significant role in endocrine and exocrine pancreatic tissues, PTF1a has gained attention in the context of studying pancreatic disorders, including diabetes and pancreatic cancer. The generation of recombinant PTF1a proteins has enabled scientists to investigate its molecular interactions, regulatory mechanisms, and potential therapeutic applications. By utilizing techniques such as recombinant DNA technology and protein expression systems, researchers aim to further elucidate the pathways regulated by PTF1a, thereby providing insights into its function and potential as a target for therapeutic interventions in pancreatic diseases. Understanding the biology and regulation of PTF1a is thus critical for advancing both basic research in developmental biology and potential clinical applications in treating pancreatic-related disorders.
