Analytical Data
-
基因名
P4Ha2
- Application
-
别名
P4Ha2；Prolyl 4-hydroxylase subunit alpha-2
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
O15460
-
表达区间
22-535aa
-
氨基酸序列
EFFTSIGHM TDLIYAEKEL VQSLKEYILV EEAKLSKIKS WANKMEALTS KSAADAEGYL AHPVNAYKLV KRLNTDWPAL EDLVLQDSAA GFIANLSVQR QFFPTDEDEI GAAKALMRLQ DTYRLDPGTI SRGELPGTKY QAMLSVDDCF GMGRSAYNEG DYYHTVLWME QVLKQLDAGE EATTTKSQVL DYLSYAVFQL GDLHRALELT RRLLSLDPSH ERAGGNLRYF EQLLEEEREK TLTNQTEAEL ATPEGIYERP VDYLPERDVY ESLCRGEGVK LTPRRQKRLF CRYHHGNRAP QLLIAPFKEE DEWDSPHIVR YYDVMSDEEI ERIKEIAKPK LARATVRDPK TGVLTVASYR VSKSSWLEED DDPVVARVNR RMQHITGLTV KTAELLQVAN YGVGGQYEPH FDFSRNDERD TFKHLGTGNR VATFLNYMSD VEAGGATVFP DLGAAIWPKK GTAVFWYNLL RSGEGDYRTR HAACPVLVGC KWVSNKWFHE RGQEFLRPCG STEVD
-
分子量
60.9 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
P4Ha2, a member of the prolyl 4-hydroxylase family, plays a critical role in the post-translational modification of collagen and other extracellular matrix proteins through the hydroxylation of proline residues. This modification is essential for the stability and function of collagen, which is vital for the structural integrity of connective tissues. Research on P4Ha2 has gained significance due to its involvement in various physiological processes and its implications in pathological conditions, including fibrosis, cancer, and cardiovascular diseases. Aberrant expression or activity of P4Ha2 has been linked to impaired collagen synthesis, leading to tissue remodeling and disease progression. Understanding the molecular mechanisms regulating P4Ha2 activity, as well as its interaction with different cellular pathways, is crucial for developing therapeutic strategies aimed at modulating its function. Recent studies have focused on the potential of P4Ha2 as a biomarker for disease states and its role in therapeutic interventions, highlighting the importance of this enzyme in both health and disease. Therefore, elucidating the biological functions and regulatory mechanisms of P4Ha2 offers a promising avenue for advancing our understanding of connective tissue disorders and developing new treatments.
