Analytical Data
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基因名
JARID1D
- Application
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别名
H-Y; Histocompatibility Y antigen; Histone demethylase JARID1D; HY; HYA; JAD1D; Jumonji AT rich interactive domain 1D (RBP2 like); Jumonji/ARID domain-containing protein 1D; KDM5D; KDM5D_HUMAN; KIAA0234; Lysine (K) specific demethylase 5D; Lysine demethylase 5D; Lysine-specific demethylase 5D; Protein SmcY
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BY66
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表达区间
127-230aa
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氨基酸序列
AICKDRRWARVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHPFDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKH
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分子量
37.07 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
JARID1D, a member of the Jumonji C domain-containing protein family, plays a crucial role in epigenetic regulation by functioning as a histone demethylase. It specifically targets di- and tri-methylated lysine residues on histone H3, thereby influencing gene expression and chromatin architecture. Research has highlighted its involvement in key biological processes, including development, stem cell maintenance, and cancer progression. JARID1D is particularly expressed in testicular tissues, indicating potential roles in male germ cell development and fertility. Abnormal expression or mutation of JARID1D has been linked to various diseases, suggesting that it may serve as a therapeutic target. The generation of recombinant JARID1D protein is critical for investigating its biochemical properties, substrate specificity, and interaction with other chromatin-modifying complexes. This protein can be utilized in enzymatic assays and structural studies to further elucidate its functional mechanisms. Understanding the role of JARID1D in gene regulation could provide insights into its potential as a biomarker or therapeutic target in cancers and other disorders associated with epigenetic dysregulation.
