Analytical Data
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基因名
KCNA3
- Application
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别名
KCNA3; HGK5; Potassium voltage-gated channel subfamily A member 3; HLK3; HPCN3; Voltage-gated K(+ channel HuKIII; Voltage-gated potassium channel subunit Kv1.3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P22001
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表达区间
1-575aa
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氨基酸序列
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
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分子量
63.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCNA3, a gene encoding a voltage-gated potassium channel (Kv1.3), plays a crucial role in regulating membrane potential and cellular excitability in various tissues, particularly in immune cells and neurons. The proteins produced by this gene are involved in maintaining cellular homeostasis and signal transduction. Dysregulation of KCNA3 has been implicated in several pathophysiological conditions, including autoimmune diseases, cancer, and neurological disorders. Research on KCNA3 and its recombinant proteins has garnered attention due to their potential as therapeutic targets. For instance, inhibiting Kv1.3 channels in immune cells can modulate inflammatory responses, making it a candidate for autoimmune therapies. Moreover, the study of KCNA3 helps unravel its role in brain function and its contribution to neurodegenerative diseases. The production of recombinant KCNA3 proteins allows for detailed biophysical characterization and the exploration of pharmacological agents that could effectively alter channel activity. By understanding the structure-function relationship of KCNA3, scientists aim to develop novel strategies for intervention in diseases where KCNA3 is a key player, highlighting its significance in both basic research and clinical applications.
