Analytical Data
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基因名
KCNE4
- Application
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别名
KCNE4; Potassium voltage-gated channel subfamily E member 4; MinK-related peptide 3; Minimum potassium ion channel-related peptide 3; Potassium channel subunit beta MiRP3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WWG9
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表达区间
1-170aa
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氨基酸序列
MLKMEPLNSTHPGTAASSSPLESRAAGGGSGNGNEYFYILVVMSFYGIFLIGIMLGYMKSKRREKKSSLLLLYKDEERLWGEAMKPLPVVSGLRSVQVPLMLNMLQESVAPALSCTLCSMEGDSVSSESSSPDVHLTIQEEGADEELEETSETPLNESSEGSSENIHQNS
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分子量
44.44 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KCNE4, a member of the KCNE family of potassium channel auxiliary subunits, plays a significant role in modulating the activity of voltage-gated potassium channels. It is primarily expressed in tissues such as the heart, brain, and lungs, where it influences key physiological functions, including cardiac repolarization and neuronal excitability. Research into KCNE4 is important because altered expression or dysfunction of this protein has been linked to various cardiac arrhythmias and other pathophysiological conditions. Furthermore, KCNE4 interacts with different potassium channel alpha subunits, particularly KCNQ1 and KCNQ4, impacting their current amplitude and gating properties. This regulatory role highlights the significance of KCNE4 in maintaining proper cellular excitability and contributes to our understanding of potassium channelopathies. Recent studies employing recombinant KCNE4 proteins have provided insights into its structure-function relationships, elucidating how specific amino acid residues influence its interactions with alpha subunits. These findings have implications for the development of targeted therapies for diseases associated with potassium channel dysregulation. Continued exploration of KCNE4 dynamics and its biological consequences is crucial for advancing our knowledge of cardiac and neuronal health, as well as potential therapeutic interventions in related disorders.
