Analytical Data
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Gene name
KIR3DL1
- Application
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Alternative Names
HLA-B;HLAB;HLA class I histocompatibility antigen. B alpha chain
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P43629
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Expression Region
361-444aa
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AA Sequence
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSTSGT IDKLDIEFHL WCSNKKNAAV MDQEPAGNRT ANSEDSDEQD PEEVTYAQLD HCVFTQRKIT RPSQRPKTPP TDTILYTELP NAKPRSKVVS CP
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Molecular Weight
15 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIR3DL1 (Killer Immunoglobulin-like Receptor 3DL1) is a pivotal immune receptor expressed on the surface of natural killer (NK) cells and certain T cells, playing a crucial role in the regulation of immune responses. It functions primarily by recognizing HLA class I molecules, thereby modulating the activity of NK cells in response to stressed, infected, or tumor-derived cells. The significance of KIR3DL1 in immune surveillance and its association with various diseases, including infectious diseases and cancer, has fueled considerable research interest. Furthermore, variations in the KIR3DL1 gene have been linked to susceptibility and resistance to certain infections and the progression of diseases, highlighting its potential as a biomarker and therapeutic target. The study of KIR3DL1 recombinant proteins offers insights into its structural and functional dynamics, enabling the exploration of its interactions with HLA molecules and downstream signaling pathways. This research not only enhances our understanding of NK cell biology but also paves the way for novel immunotherapeutic strategies aimed at modulating KIR3DL1 activity to improve immune responses against malignancies and infectious agents.
