Analytical Data
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基因名
KIAA1310
- Application
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别名
K1310_HUMAN; KAT8 regulatory NSL complex subunit 3; Kiaa1310; Non specific lethal 3 homolog; NSL complex protein NSL3; NSL3; Rcd1; Serum inhibited-related protein; Testis development protein PRTD; Uncharacterized protein KIAA1310
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9P2N6
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表达区间
1-791aa
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氨基酸序列
MPLYDNQKARSVMNECERHVIFARTDADAPPPPEDWEEHVNRTGWTMAQNKLFNKILKALQSDRLARLANEGACNEPVLRRVAVDKCARRVRQALASVSWDTKLIQWLHTTLVETLSLPMLAAYLDALQTLKGKIPTLIDRMLVSSNTKTGAAGAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILIASSGPSSSVFPTSRRHRFWQSQLSCLGKVIPVATHLLNNGSGVGVLQCLEHMIGAVRSKVLEIHSHFPHKPIILIGWNTGALVACHVSVMEYVTAVVCLGFPLLTVDGPRGDVDDPLLDMKTPVLFVIGQNSLQCHPEAMEDFREKIRAENSLVVVGGADDNLRISKAKKKSEGLTQSMVDRCIQDEIVDFLTGVLTRAEGHMGSEPRDQDAEKKKKPRDVARRDLAFEVPERGSRPASPAAKLPASPSGSEDLSSVSSSPTSSPKTKVTTVTSAQKSSQIGSSQLLKRHVQRTEAVLTHKQAQVPISSEPPEEGEKEDLRVQLKRHHPSSPLPGSKTSKRPKIKVSLISQGDTAGGPCAPSQGSAPEAAGGKPITMTLGQASAGAKELTGLLTTAKSSSSEGGVSASPVPSVVSSSTAPSALHTLQSRLVATSPGSSLPGATSASSLLQGLSFSLQDISSKTSGLPANPSPGPAPQATSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLGATPGGKPTAIHQLLTNGGLAKLASSLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGAAPSEESSSQVLPSSSQRLPPAP
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分子量
109.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIAA1310, also known as ORC5L (Origin Recognition Complex Subunit 5-Like), is a protein that plays a critical role in the initiation of DNA replication, a fundamental process for cell division and proliferation. Research on KIAA1310 has gained traction due to its involvement in the formation of the pre-replication complex, which is crucial for ensuring that DNA replication occurs accurately and at the appropriate times during the cell cycle. Abnormalities in the regulation or function of KIAA1310 have been linked to various forms of cancer, as unchecked cell proliferation can lead to tumorigenesis. Moreover, KIAA1310 has been implicated in other cellular processes such as DNA repair, thus raising its profile in studies related to genomic stability. Understanding the structure and function of recombinant KIAA1310 is essential for elucidating its role in cellular biology and its potential as a therapeutic target. Researchers are particularly interested in its mechanisms of action, interaction partners, and how post-translational modifications might affect its function, which could pave the way for developing novel strategies in cancer treatment and gene therapy. Overall, the study of KIAA1310 could offer valuable insights into cell cycle regulation, DNA replication fidelity, and the molecular underpinnings of various diseases, highlighting its significance in both fundamental biology and clinical research.
