Analytical Data
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Gene name
KIAA1598
- Application
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Alternative Names
SHTN1; KIAA1598; Shootin-1; Shootin1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A0MZ66
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Expression Region
1-631aa
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AA Sequence
MNSSDEEKQL QLITSLKEQA IGEYEDLRAE NQKTKEKCDK IRQERDEAVK KLEEFQKISH MVIEEVNFMQ NHLEIEKTCR ESAEALATKL NKENKTLKRI SMLYMAKLGP DVITEEINID DEDSTTDTDG AAETCVSVQC QKQIKELRDQ IVSVQEEKKI LAIELENLKS KLVEVIEEVN KVKQEKTVLN SEVLEQRKVL EKCNRVSMLA VEEYEEMQVN LELEKDLRKK AESFAQEMFI EQNKLKRQSH LLLQSSIPDQ QLLKALDENA KLTQQLEEER IQHQQKVKEL EEQLENETLH KEIHNLKQQL ELLEEDKKEL ELKYQNSEEK ARNLKHSVDE LQKRVNQSEN SVPPPPPPPP PLPPPPPNPI RSLMSMIRKR SHPSGSGAKK EKATQPETTE EVTDLKRQAV EEMMDRIKKG VHLRPVNQTA RPKTKPESSK GCESAVDELK GILGTLNKST SSRSLKSLDP ENSETELERI LRRRKVTAEA DSSSPTGILA TSESKSMPVL GSVSSVTKTA LNKKTLEAEF NSPSPPTPEP GEGPRKLEGC TSSKVTFQPP SSIGCRKKYI DGEKQAEPVV VLDPVSTHEP QTKDQVAEKD PTQHKEDEGE IQPENKEDSI ENVRETDSSN C
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Molecular Weight
71.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KIAA1598, also known as TET2, is a gene that has garnered significant interest in recent years due to its role in various biological processes and disease mechanisms, particularly in cancer. Initial studies highlighted its involvement in cellular differentiation and development, as KIAA1598 encodes a protein that interacts with other nuclear factors, influencing gene expression and chromatin remodeling. The protein's functions are particularly crucial in hematopoiesis, where mutations in the KIAA1598 gene have been linked to hematological malignancies such as acute myeloid leukemia (AML). Given the potential implications for cancer treatment, researchers are focusing on the recombinant protein form of KIAA1598 to better understand its structure-function relationships and biochemical pathways. By utilizing recombinant DNA technology, scientists can produce large quantities of the protein to investigate its enzymatic activities and interactions with other cellular components. Such studies may reveal critical insights into the molecular mechanisms driving malignancies and could lead to the development of targeted therapies. Furthermore, understanding KIAA1598's role in epigenetic regulation may contribute to the advancement of personalized medicine, as altered expression of TET2 has been associated with distinct clinical outcomes in cancer patients. Overall, the research on KIAA1598 recombinant protein not only sheds light on fundamental biological processes but also opens avenues for innovative therapeutic strategies in oncology.
