Analytical Data
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Gene name
Ccn6
- Application
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Alternative Names
Ccn6；WISP3；Cellular communication network factor 6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95389
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Expression Region
24-354aa
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AA Sequence
TGPLDTT PEGRPGEVSD APQRKQFCHW PCKCPQQKPR CPPGVSLVRD GCGCCKICAK QPGEICNEAD LCDPHKGLYC DYSVDRPRYE TGVCAYLVAV GCEFNQVHYH NGQVFQPNPL FSCLCVSGAI GCTPLFIPKL AGSHCSGAKG GKKSDQSNCS LEPLLQQLST SYKTMPAYRN LPLIWKKKCL VQATKWTPCS RTCGMGISNR VTNENSNCEM RKEKRLCYIQ PCDSNILKTI KIPKGKTCQP TFQLSKAEKF VFSGCSSTQS YKPTFCGICL DKRCCIPNKS KMITIQFDCP NEGSFKWKML WITSCVCQRN CREPGDIFSE LKIL
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Molecular Weight
39.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Ccn6, also known as Cyclin D3, is a member of the cyclin family that plays a pivotal role in cell cycle regulation, particularly in the transition from the G1 phase to the S phase, thereby influencing cell proliferation and differentiation. Its function is critical in various biological processes, including embryonic development and tissue homeostasis. Dysregulation of Ccn6 has been implicated in various cancers, making it a potential therapeutic target and a biomarker for cancer progression. Recent studies have focused on the expression, purification, and characterization of recombinant Ccn6 protein to better understand its structure-function relationship and its role in oncogenic signaling pathways. The production of recombinant Ccn6 in heterologous systems can facilitate biochemical assays and structural studies, which are essential for drug discovery and development. Understanding the interactions of Ccn6 with other cellular proteins and its post-translational modifications can provide insights into the mechanisms underlying cell cycle control and tumorigenesis. Moreover, the recombinant protein could be exploited in the development of novel therapeutic strategies aimed at restoring the normal function of cyclins in cancer cells. Thus, the research on Ccn6 recombinant protein not only enhances our knowledge of cell cycle dynamics but also holds significant potential for advancing cancer therapeutics.
