Analytical Data
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Gene name
MAP3K12
- Application
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Alternative Names
MBIP;MAP3K12-binding inhibitory Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NS73
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Expression Region
1-344aa
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AA Sequence
MAAATELNRPSSGDRNLERRCRPNLSREVLYEIFRSLHTLVGQLDLRDDVVKITIDWNKLQSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVEEIGRTEMGNKNEVNDKFSIGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVREFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVNTYGPQTRPEGIPGSGHKPNSMLRDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVSFSGKRRKVQPPQQNYSLAELDEKISALKQALLRKSREAESMATHHLP
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Molecular Weight
94 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MAP3K12, also known as Mitogen-Activated Protein Kinase Kinase Kinase 12, is a serine/threonine kinase that plays a crucial role in the MAPK signaling pathway, which is involved in various cellular processes including proliferation, differentiation, and apoptosis. Its importance in cellular communication and response to extracellular signals has drawn significant research interest, particularly in the context of cancer biology, where abnormal activation of MAPK pathways is often implicated. The study of MAP3K12's structure and function can provide insights into its specific roles in these processes. Recombining MAP3K12 allows researchers to produce the protein in a controlled environment, facilitating detailed investigations into its biochemical properties, interactions with other signaling molecules, and contributions to disease mechanisms. Additionally, analyzing MAP3K12 may reveal potential therapeutic targets or biomarkers for diseases associated with dysregulated MAPK signaling. Thus, understanding MAP3K12 at the molecular level is essential for advancing our knowledge of intricate cellular networks and developing effective treatments for related pathologies.
