Analytical Data
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Gene name
KRTAP6-3
- Application
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Alternative Names
KRTAP6-3; KAP6.3Keratin-associated protein 6-3
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q3LI67
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Expression Region
1-110aa
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AA Sequence
MTSTTNTMCGSYYRNYNGGHGYGCCGYGGLGCGYGGCGYGCCGYGGLGFGYGGLDCGYGGLGCGYGSFCGCGYRGLDCGYGCGYGYVSHSFCGCGYRCGSGYGSSFGYYY
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Molecular Weight
12.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRTAP6-3 (Keratin Associated Protein 6-3) is a member of the keratin-associated protein family, which plays a crucial role in the structural integrity and properties of hair, skin, and nails. Research into KRTAP6-3 has gained significance due to its potential impact on various dermatological conditions and hair disorders. Understanding the function and regulation of KRTAP6-3 may provide insights into the molecular mechanisms of keratinization processes and the development of skin and hair abnormalities. Mutations or dysregulation of KRTAP genes are implicated in disorders such as hypotrichosis and other ectodermal dysplasias, making the study of KRTAP6-3 particularly relevant in clinical genetics and dermatology. Moreover, the characterization of KRTAP6-3 as a recombinant protein facilitates the exploration of its biochemical properties, interactions with other keratin proteins, and contributions to the assembly of the keratin intermediate filament network. This research is essential not only for advancing our understanding of keratin biology but also for developing potential therapeutic approaches aimed at treating hair and skin-related diseases. The recombinant production of KRTAP6-3 allows for detailed functional studies and may pave the way for innovative strategies in regenerative medicine and tissue engineering, thus highlighting the importance of KRTAP6-3 in both basic research and clinical applications.
