Analytical Data
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基因名
KAL1
- Application
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别名
KAL1；KLK3；Plasma kallikrein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P23352
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表达区间
384-680aa
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氨基酸序列
RLKSAKVSLH FTSTHATNNK EQLVKTRKGG IQTQLPFQRR RPTRPLEVGA PFYQDGQLQV KVYWKKTEDP TVNRYHVRWF PEACAHNRTT GSEASSGMTH ENYIILQDLS FSCKYKVTVQ PIRPKSHSKA EAVFFTTPPC SALKGKSHKP VGCLGEAGHV LSKVLAKPEN LSASFIVQDV NITGHFSWKM AKANLYQPMT GFQVTWAEVT TESRQNSLPN SIISQSQILP SDHYVLTVPN LRPSTLYRLE VQVLTPGGEG PATIKTFRTP ELPPSSAHRS HLKHRHPHHY KPSPERY
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分子量
36 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KAL1, or Kallmann syndrome 1 protein, is a significant protein involved in the development of the olfactory system and reproductive functions in humans. Mutations in the KAL1 gene have been linked to Kallmann syndrome, a genetic condition characterized by the absence of the sense of smell (anosmia) and hypogonadotropic hypogonadism, leading to delayed or absent puberty and reduced reproductive capability. The significance of KAL1 in neurodevelopment and hormonal regulation has spurred considerable interest in understanding its structure, function, and potential therapeutic applications. Research on KAL1 recombinant protein has focused on elucidating its role in neuronal migration and the signaling pathways involved in gonadotropin-releasing hormone (GnRH) neuron development. This has implications for both basic neuroscience and clinical approaches to treat reproductive disorders. Producing KAL1 as a recombinant protein enables researchers to study its properties in detail, including its interactions with other proteins and its effect on cellular processes. Additionally, understanding KAL1's mechanisms could lead to novel interventions for conditions arising from its dysfunction, paving the way for advancements in gene therapy and regenerative medicine for individuals affected by Kallmann syndrome and related disorders.
