Analytical Data
-
Gene name
LMBR1
- Application
-
Alternative Names
ACHP; C7orf2; DIF 14; DIF14; Differentiation related gene 14; Differentiation related gene 14 protein; Differentiation-related gene 14 protein; FLJ11665; Limb region 1 homolog (mouse); Limb region 1 homolog; Limb region 1 protein; Limb region 1 protein homolog; LMBR 1; LMBR1; LMBR1_HUMAN; OTTHUMP00000211720; PPD 2; PPD2; TPT
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q8WVP7
-
Expression Region
1-490aa
-
AA Sequence
MEGQDEVSAREQHFHSQVRESTICFLLFAILYVVSYFIITRYKRKSDEQEDEDAIVNRISLFLSTFTLAVSAGAVLLLPFSIISNEILLSFPQNYYIQWLNGSLIHGLWNLASLFSNLCLFVLMPFAFFFLESEGFAGLKKGIRARILETLVMLLLLALLILGIVWVASALIDNDAASMESLYDLWEFYLPYLYSCISLMGCLLLLLCTPVGLSRMFTVMGQLLVKPTILEDLDEQIYIITLEEEALQRRLNGLSSSVEYNIMELEQELENVKTLKTKLERRKKASAWERNLVYPAVMVLLLIETSISVLLVACNILCLLVDETAMPKGTRGPGIGNASLSTFGFVGAALEIILIFYLMVSSVVGFYSLRFFGNFTPKKDDTTMTKIIGNCVSILVLSSALPVMSRTLGITRFDLLGDFGRFNWLGNFYIVLSYNLLFAIVTTLCLVRKFTSAVREELFKALGLHKLHLPNTSRDSETAKPSVNGHQKAL
-
Molecular Weight
81.5 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LMBR1 (Limb Development Membrane Protein 1) is a pivotal gene implicated in limb and organ morphogenesis, with significant roles in developmental biology and congenital disorder research. Mutations or aberrations in this gene can lead to serious malformations, particularly affecting limb formation, which has made it a subject of great interest in medical genetics. Research into LMBR1 has revealed its involvement in various signaling pathways, including those related to the Shh (Sonic Hedgehog) pathway, crucial for proper limb development. The study of LMBR1 recombinant proteins is essential for elucidating its functional mechanisms and interactions within these pathways. By producing and characterizing LMBR1 recombinant proteins, researchers can investigate the protein’s structure-function relationship, binding affinities, and effects on cellular behaviors, such as proliferation and differentiation in limb bud cultures. Furthermore, understanding how LMBR1 influences embryonic development has implications for developing therapeutic strategies for congenital malformations and related conditions. As a result, advances in techniques for the recombination and purification of LMBR1 proteins will facilitate deeper insights into its biological roles and potential applications in regenerative medicine and genetic therapies. This exploration not only contributes to fundamental biological knowledge but also offers hope for preventing and treating limb-related congenital disorders, making LMBR1 a key focus in developmental biology and medical research.
