Analytical Data
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基因名
NDRG1
- Application
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别名
NDRG1;CAP43;DRG1;RTP;Protein NDRG1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92597
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表达区间
2-394aa
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氨基酸序列
SREMQDVDL AEVKPLVEKG ETITGLLQEF DVQEQDIETL HGSVHVTLCG TPKGNRPVIL TYHDIGMNHK TCYNPLFNYE DMQEITQHFA VCHVDAPGQQ DGAASFPAGY MYPSMDQLAE MLPGVLQQFG LKSIIGMGTG AGAYILTRFA LNNPEMVEGL VLINVNPCAE GWMDWAASKI SGWTQALPDM VVSHLFGKEE MQSNVEVVHT YRQHIVNDMN PGNLHLFINA YNSRRDLEIE RPMPGTHTVT LQCPALLVVG DSSPAVDAVV ECNSKLDPTK TTLLKMADCG GLPQISQPAK LAEAFKYFVQ GMGYMPSASM TRLMRSRTAS GSSVTSLDGT RSRSHTSEGT RSRSHTSEGT RSRSHTSEGA HLDITPNSGA AGNSAGPKSM EVSC
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NDRG1 (N-Myc downstream-regulated gene 1) is a protein that plays a significant role in various biological processes, including cell differentiation, growth regulation, and stress responses. It was initially identified as a gene that is downregulated by the oncogene N-Myc in neuroblastoma cells. Since its discovery, extensive research has shown that NDRG1 is implicated in several pathological conditions, including cancer progression and metastasis, where it often exhibits tumor-suppressive properties. Additionally, NDRG1 has been linked to the regulation of cellular responses to hypoxia and oxidative stress, making it a potential biomarker for various diseases, including cardiovascular disorders and neurological diseases. Recent studies have focused on understanding the molecular mechanisms underlying NDRG1's functions, exploring its role in signaling pathways related to cell survival and apoptosis. The production of recombinant NDRG1 protein has become crucial for these research efforts, as it allows for detailed structural and functional analyses. Recombinant NDRG1 can be utilized in biochemical assays, drug discovery, and as a therapeutic target, providing insights into its potential as a biomarker and therapeutic agent in clinical applications. Thus, the study of NDRG1 and its recombinant form continues to be a vital area of research, with implications for understanding cancer biology and developing novel therapeutic strategies.
