Analytical Data
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Gene name
LRRK1
- Application
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Alternative Names
KIAA1790; Leucine rich repeat serine/threonine protein kinase 1; Leucine-rich repeat serine/threonine-protein kinase 1; LRRK 1; Lrrk1; LRRK1_HUMAN; RIPK6; Roco1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q38SD2
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Expression Region
1-261aa
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AA Sequence
MSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTRGGDPAARSRRTEGIRAAYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEMVRYLLSKRLVELPTEPTDDNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALACQRGHLGVVKLLVLTHGADPESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGAYFCSYILLDSPDPSKHLLRKYFIEASPLPSSYPGKTVSSHCLWSVF
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Molecular Weight
55 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LRRK1 (Leucine-Rich Repeat Kinase 1) is a member of the LRRK family of proteins, which are implicated in various cellular processes such as signal transduction, cytoskeletal dynamics, and autophagy. Extensive research into LRRK1 has emerged due to its structural similarities with the well-studied LRRK2, a protein linked to Parkinson's disease. Unlike LRRK2, however, the biological role of LRRK1 remains less understood, making it a compelling subject for investigation. Initial studies have suggested that LRRK1 may play a role in regulating immune responses and neuronal functions, which positions it as a potential player in neurodegenerative diseases and inflammatory conditions. Recent advances in recombinant protein technologies have facilitated the production and purification of LRRK1, allowing researchers to explore its enzymatic activities and interactions with various substrates in greater detail. Understanding the biochemical properties and molecular pathways associated with LRRK1 is crucial for elucidating its potential functions and therapeutic implications. As research unfolds, LRRK1 is increasingly recognized not only for its similarities to LRRK2 but also for its unique characteristics that may contribute to various pathologies, highlighting the need for comprehensive studies of this enzyme in both health and disease contexts.
