Analytical Data
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Gene name
CXCR3
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简介
The CXCR3 protein acts as a receptor for CXC chemokines (CXCL9, CXCL10, and CXCL11), affecting human mesangial cells (HMC) through G protein signaling. It binds CCL21 and may promote cell chemotaxis. CXCR3 Protein, Human (Cell-Free, His) is the recombinant human-derived CXCR3 protein, expressed by E. coli Cell-free , with C-10*His labeled tag.
- Application
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Alternative Names
CD183; CKR-L2; CMKAR3; GPR9; IP10r; IP10-R; Mig-R; MigR; G Protein-Coupled Receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor
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Species
Human
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Source
E. coli Cell-free
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Tag
C-10*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49682-1
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Expression Region
M1-L368
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AA Sequence
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
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Protein Length
Full Length of Isoform-1
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Molecular Weight
44 kDa (Monomer) & 90 kDa (Dimer)
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CXCR3 is a chemokine receptor that plays a crucial role in the immune system, particularly in the trafficking of effector T cells and the regulation of immune responses. It is expressed on T cell subpopulations, including Th1 cells, and is involved in the migration of these cells to sites of inflammation and infection. The receptor is activated by specific chemokines such as CXCL9, CXCL10, and CXCL11, which are important in mediating immune responses against various pathogens and in inflammatory diseases. Research on CXCR3 has gained momentum due to its involvement in conditions such as autoimmune diseases, cancers, and chronic infections. The production of recombinant CXCR3 protein allows researchers to study the receptor's structure, binding affinities, and downstream signaling pathways in detail. This understanding can provide insights into how CXCR3 influences immune cell behavior and may help identify potential therapeutic targets for modulating immune responses. Advances in recombinant DNA technology have made it feasible to produce and purify CXCR3, enabling studies that explore its functional roles in health and disease, supporting the development of novel interventions aimed at enhancing or inhibiting its activity for therapeutic benefit. As such, recombinant CXCR3 protein serves as a valuable tool in the quest to decipher the complexities of immune responses and develop strategies for treating related disorders.
