Analytical Data
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Gene name
MAEL
- Application
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Alternative Names
cancer/testis antigen 128; CT128; FLJ14904; mael; MAEL_HUMAN; maelstrom homolog (Drosophila); Maelstrom homolog; OTTHUMP00000032344; Protein maelstrom homolog; RP11-102C16.1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96JY0
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Expression Region
1-434aa
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AA Sequence
MPNRKASRNA YYFFVQEKIP ELRRRGLPVA RVADAIPYCS SDWALLREEE KEKYAEMARE WRAAQGKDPG PSEKQKPVFT PLRRPGMLVP KQNVSPPDMS ALSLKGDQAL LGGIFYFLNI FSHGELPPHC EQRFLPCEIG CVKYSLQEGI MADFHSFINP GEIPRGFRFH CQAASDSSHK IPISNFERGH NQATVLQNLY RFIHPNPGNW PPIYCKSDDR TRVNWCLKHM AKASEIRQDL QLLTVEDLVV GIYQQKFLKE PSKTWIRSLL DVAMWDYSSN TRCKWHEEND ILFCALAVCK KIAYCISNSL ATLFGIQLTE AHVPLQDYEA SNSVTPKMVV LDAGRYQKLR VGSSGFSHFN SSNEEQRSNT PIGDYPSRAK ISGQNSSVRG RGITRLLESI SNSSSNIHKF SNCDTSLSPY MSQKDGYKSF SSLS
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Molecular Weight
49.2 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAEL (Maelstrom protein) is a highly conserved protein that plays a crucial role in germ cell development and genomic stability. Initially identified in Drosophila, MAEL has garnered interest in various fields, including developmental biology and reproductive health. Its ancestral function is linked to the regulation of gene expression and the formation of piRNA complexes, which are essential for transposon silencing in the germline. Dysregulation of MAEL has been associated with infertility and other reproductive disorders, highlighting its significance in the maintenance of germ cell integrity. Recent studies have expanded our understanding of MAEL’s interaction with other cellular pathways and its potential implications in cancer biology, where it may influence tumorigenesis through similar mechanisms of genomic regulation. Researchers are actively investigating the biochemical properties of MAEL and its role in spermatogenesis, with the aim of uncovering new therapeutic targets for reproductive health issues and understanding its broader implications in stem cell biology and tumor development. The ongoing exploration of MAEL provides valuable insights into the intricate network of gene regulation involved in germ cell biology and its potential consequences for human health.
