Analytical Data
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Gene name
MC1R
- Application
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Alternative Names
CMM5; MC1 Receptor; MC1-R; MC1R; Melanocortin 1 receptor ; Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); Melanocortin receptor 1; Melanocyte-stimulating hormone receptor; Melanotropin receptor; MSH-R; MSHR; MSHR_HUMAN; SHEP2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q01726
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Expression Region
1-317aa
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AA Sequence
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSTVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
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Molecular Weight
61.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of MC1R (melanocortin-1 receptor) recombinant protein is rooted in its pivotal role in skin pigmentation and response to ultraviolet (UV) radiation. MC1R is a G-protein coupled receptor predominantly expressed in melanocytes, where it regulates the synthesis of melanin, the pigment responsible for skin, hair, and eye color. Variations in the MC1R gene have been linked to red hair, fair skin, and an increased risk of skin cancers, making it a significant focus of research in dermatology and genetics. Understanding the molecular mechanisms by which MC1R modulates melanin production can provide insights into pigmentation disorders and potential therapeutic targets for skin cancer prevention. The recombinant expression of MC1R allows scientists to study its structure, functionality, and interactions with various ligands in detail. By utilizing recombinant protein technology, researchers can investigate how different mutations impact receptor activity and downstream signaling pathways, ultimately shedding light on the diverse physiological roles of MC1R beyond pigmentation. Additionally, the generated recombinant proteins serve as valuable tools for drug screening and the development of MC1R-targeted therapies, which could lead to innovative treatments for hyperpigmentation disorders and skin cancer prevention. Overall, the exploration of MC1R recombinant protein represents a critical intersection of molecular biology, biotechnology, and clinical research, underscoring its relevance in medical and cosmetic applications.
