Analytical Data
-
基因名
MC1R
- Application
-
别名
CMM5; MC1 Receptor; MC1-R; MC1R; Melanocortin 1 receptor ; Melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); Melanocortin receptor 1; Melanocyte-stimulating hormone receptor; Melanotropin receptor; MSH-R; MSHR; MSHR_HUMAN; SHEP2
-
种属
Human
-
表达系统
E. coli
-
标签
GST-tag at N-terminal
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q01726
-
表达区间
1-317aa
-
氨基酸序列
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSTVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
-
分子量
61.1 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of MC1R (melanocortin-1 receptor) recombinant protein is rooted in its pivotal role in skin pigmentation and response to ultraviolet (UV) radiation. MC1R is a G-protein coupled receptor predominantly expressed in melanocytes, where it regulates the synthesis of melanin, the pigment responsible for skin, hair, and eye color. Variations in the MC1R gene have been linked to red hair, fair skin, and an increased risk of skin cancers, making it a significant focus of research in dermatology and genetics. Understanding the molecular mechanisms by which MC1R modulates melanin production can provide insights into pigmentation disorders and potential therapeutic targets for skin cancer prevention. The recombinant expression of MC1R allows scientists to study its structure, functionality, and interactions with various ligands in detail. By utilizing recombinant protein technology, researchers can investigate how different mutations impact receptor activity and downstream signaling pathways, ultimately shedding light on the diverse physiological roles of MC1R beyond pigmentation. Additionally, the generated recombinant proteins serve as valuable tools for drug screening and the development of MC1R-targeted therapies, which could lead to innovative treatments for hyperpigmentation disorders and skin cancer prevention. Overall, the exploration of MC1R recombinant protein represents a critical intersection of molecular biology, biotechnology, and clinical research, underscoring its relevance in medical and cosmetic applications.
