Analytical Data
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基因名
PNOC
- Application
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别名
PNOC;OFQ;Prepronociceptin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13519
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表达区间
20-176aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSSCQRDCL TCQEKLHPAL DSFDLEVCIL ECEEKVFPSP LWTPCTKVMA RSSWQLSPAA PEHVAAALYQ PRASEMQHLR RMPRVRSLFQ EQEEPEPGME EAGEMEQKQL QKRFGGFTGA RKSARKLANQ KRFSEFMRQY LVLSMQSSQR RRTLHQNGNV
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分子量
21 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PNOC, or prepronociceptin, is a propeptide that is cleaved into multiple bioactive peptides, including nociceptin/orphanin FQ (N/OFQ), which plays a pivotal role in pain modulation, stress response, and various neurobiological processes. The study of PNOC and its derived peptides has gained significant interest due to their potential implications in pain management and therapeutic strategies for various neurological disorders. Researchers have been exploring the molecular mechanisms by which N/OFQ interacts with its receptor, the nociceptin receptor (NOP), to understand how it influences pain perception and emotional regulation. Additionally, alterations in the PNOC system have been associated with several pathological conditions, including chronic pain, addiction, and anxiety disorders, making it a critical target for drug development. Recent advances in molecular biology and pharmacology have facilitated the characterization of PNOC's role in both central and peripheral nervous systems, leading to a deeper understanding of its therapeutic potential. Overall, the ongoing research into PNOC and its signaling pathways is poised to unveil novel approaches for treating pain and related disorders, positioning it at the forefront of neuroscience and pharmacological research.
