Analytical Data
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Gene name
MKI67IP
- Application
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Alternative Names
hNIFK; MK67I_HUMAN; MKI67 FHA Domain Interacting Nucleolar Phosphoprotein; MKI67 FHA domain-interacting nucleolar phosphoprotein; mki67ip; NOPP34; Nucleolar phosphoprotein Nopp34; Nucleolar protein interacting with the FHA domain of pKI 67; Nucleolar protein interacting with the FHA domain of pKI-67; pKi67
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BYG3
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Expression Region
2-293 aa
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AA Sequence
ATFSGPAGP ILSLNPQEDV EFQKEVAQVR KRITQRKKQE QLTPGVVYVR HLPNLLDETQ IFSYFSQFGT VTRFRLSRSK RTGNSKGYAF VEFESEDVAK IVAETMNNYL FGERLLECHF MPPEKVHKEL FKDWNIPFKQ PSYPSVKRYN RNRTLTQKLR MEERFKKKER LLRKKLAKKG IDYDFPSLIL QKTESISKTN RQTSTKGQVL RKKKKKVSGT LDTPEKTVDS QGPTPVCTPT FLERRKSQVA ELNDDDKDDE IVFKQPISCV KEEIQETQTP THSRKKRRRS SNQ
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Molecular Weight
34.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The MKI67IP (MKI67 Interacting Protein) is a crucial protein involved in the regulation of cell proliferation and the cell cycle. It has garnered significant research interest due to its role in cancer biology, particularly in the context of tumor growth and progression. MKI67IP is known to interact with the Ki-67 protein, a well-established marker of cellular proliferation, thereby influencing the processes of mitosis and chromatin dynamics. Studies have suggested that MKI67IP may contribute to the maintenance of cell division and could be a potential target for therapeutic interventions in various cancers. Furthermore, understanding the molecular mechanisms underlying its function may provide insights into the dysregulation of cell proliferation in cancerous tissues. As researchers delve deeper into the role of MKI67IP, its potential implications in diagnostics and treatment strategies continue to be a focal point, highlighting the importance of this protein in oncology research. Given the increasing incidence of cancer worldwide, the investigation of MKI67IP and its related pathways is not only timely but also critical for developing novel approaches to improve patient outcomes.
