Analytical Data
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基因名
MNT
- Application
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别名
Max-binding protein MNT. Class D basic helix-loop-helix protein 3. bHLHd3. Myc antagonist MNT. Protein ROX
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99583
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表达区间
1-582 aa
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氨基酸序列
MSIETLLEAARFLEWQAQQQQRAREEQERLRLEQEREQEQKKANSLARLAHTLPVEEPRMEAPPLPLSPPAPPPAPPPPLATPAPLTVIPIPVVTNSPQPLPPPPPLPAAAQPLPLAPRQPALVGAPGLSIKEPAPLPSRPQVPTPAPLLPDSKATIPPNGSPKPLQPLPTPVLTIAPHPGVQPQLAPQQPPPPTLGTLKLAPAEEVKSSEQKKRPGGIGTREVHNKLEKNRRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRKEKEYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTASEGEDNIDEDMEEDRAGLGPPKLSHRPQPELLKSTLPPPSTTPAPLPPHPHPHPHSVALPPAHLPVQQQQPQQKTPLPAPPPPPAAPAQTLVPAPAHLVATAGGGSTVIAHTATTHASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPIGHITVHPATLNHVAHLGSQLPLYPQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQLVGQTVLNPVTMVTMPSFPVSTLKLA
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分子量
88.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MNT (Myc Network Target) is a protein that plays a crucial role in the regulation of gene expression and cellular pathways, particularly in the context of cellular growth, differentiation, and apoptosis. It acts as a transcriptional repressor and is known to interact with various other proteins involved in the Myc signaling network, which is pivotal in cancer biology and the regulation of cell proliferation. Research into MNT and its associated pathways has garnered interest due to the protein's potential implications in tumorigenesis and its ability to influence the balance between cell proliferation and programmed cell death. Studies have indicated that MNT can modulate the activity of oncogenic Myc, thereby providing a unique perspective on how this interaction may be harnessed for therapeutic applications. Understanding MNT's structure, function, and the molecular mechanisms underlying its regulatory roles could pave the way for developing novel strategies in cancer treatment, as well as in regenerative medicine where modulation of cell fate is crucial. Consequently, the study of recombinant MNT proteins has become a focal point in molecular biology research, aiming to elucidate their functionality and explore their potential as biomarkers or therapeutic targets in various diseases.
