Analytical Data
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基因名
MRPL3
- Application
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别名
39S ribosomal protein L3; 39S ribosomal protein L3 mitochondrial; COXPD9; L3mt; Mitochondrial 39S ribosomal protein L3; Mitochondrial 60S ribosomal protein L3; mitochondrial; mitochondrial ribosomal protein; Mitochondrial ribosomal protein L3; MRL3; MRP-L3; MRPL3; RM03_HUMAN; RPML3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P09001
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表达区间
1-348 aa
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氨基酸序列
MPGWRLLTQV GAQVLGRLGD GLGAALGPGN RTHIWLFVRG LHGKSGTWWD EHLSEENVPF IKQLVSDEDK AQLASKLCPL KDEPWPIHPW EPGSFRVGLI ALKLGMMPLW TKDGQKHVVT LLQVQDCHVL KYTSKENCNG KMATLSVGGK TVSRFRKATS ILEFYRELGL PPKQTVKIFN ITDNAAIKPG TPLYAAHFRP GQYVDVTAKT IGKGFQGVMK RWGFKGQPAT HGQTKTHRRP GAVATGDIGR VWPGTKMPGK MGNIYRTEYG LKVWRINTKH NIIYVNGSVP GHKNCLVKVK DSKLPAYKDL GKNLPFPTYF PDGDEEELPE DLYDENVCQP GAPSITFA
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分子量
38.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRPL3, or mitochondrial ribosomal protein L3, plays a critical role in mitochondrial protein synthesis, which is essential for oxidative phosphorylation and cellular energy production. Abnormalities in MRPL3 have been associated with various mitochondrial diseases and disorders, including encephalomyopathy and cardiomyopathy. Understanding the structure and function of MRPL3 is vital for elucidating the mechanisms underlying these conditions and for developing potential therapeutic strategies. The study of MRPL3 recombinant proteins allows researchers to investigate its biochemical properties, interactions with other mitochondrial components, and its role in ribosome assembly and function. Moreover, the characterization of MRPL3 can shed light on the evolutionary aspects of mitochondrial ribosomes and their divergence from bacterial systems. Recent advances in techniques such as cryo-electron microscopy and X-ray crystallography have enabled a more detailed analysis of MRPL3 and its complexes, paving the way for the identification of mutation effects and potential drug targets. As mitochondrial dysfunction is a critical factor in aging and various pathologies, further research into MRPL3 recombinant proteins holds significant promise for enhancing our understanding of mitochondrial biology and its implications in health and disease.
