Analytical Data
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Gene name
ABCA7
- Application
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Alternative Names
ABCA7；Phospholipid-transporting ATPase ABCA7
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IZY2
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Expression Region
全长
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AA Sequence
full
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Molecular Weight
234.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ABCA7 (ATP-binding cassette sub-family A member 7) is a gene that encodes a membrane protein involved in lipid metabolism and the clearance of amyloid-beta (Aβ) peptides, which are critical in the pathogenesis of Alzheimer's disease. It is a member of the ABC transporter family, which plays a significant role in transporting various molecules across membranes. Studies have indicated that variations in the ABCA7 gene are associated with an increased risk of Alzheimer's disease, suggesting its potential involvement in cognitive decline and neurodegeneration. The protein is primarily expressed in macrophages and the brain, where it is believed to facilitate the efflux of cholesterol and phospholipids, thereby influencing the formation and accumulation of amyloid plaques. Understanding the structure and function of ABCA7 is crucial, as it may reveal novel therapeutic targets for Alzheimer's disease and other neurodegenerative disorders. Recent research has focused on the characterization of ABCA7's domain structure, its interactions with lipids and other proteins, and the regulatory mechanisms governing its expression and activity. As the link between ABCA7 and Alzheimer's disease becomes clearer, ongoing studies aim to elucidate its precise role in neuroinflammation, neuroprotection, and synaptic function, paving the way for potential interventions that could mitigate Alzheimer-related pathology.
