Analytical Data
-
基因名
MTM1
- Application
-
别名
Phosphatidylinositol-3.5-bisphosphate 3-phosphatase ;Phosphatidylinositol-3-phosphate phosphatase
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q13496
-
表达区间
1-603 aa
-
氨基酸序列
MASASTSKYNSHSLENESIKRTSRDGVNRDLTEAVPRLPGETLITDKEVIYICPFNGPIKGRVYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATSRGENSYGLDITCKDMRNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFNVDGWTVYNPVEEYRRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRVLYPVASMRHLELWVNYYIRWNPRIKQQQPNPVEQRYMELLALRDEYIKRLEELQLANSAKLSDPPTSPSSPSQMMPHVQTHF
-
分子量
71.4 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MTM1 (Myotubularin 1) is a critical protein involved in the regulation of lipid metabolism and intracellular signaling pathways, particularly in the context of muscle function and development. Mutations in the MTM1 gene are primarily associated with X-linked myotubular myopathy, a severe inherited muscle disorder characterized by muscle weakness and atrophy. Research into MTM1 has gained momentum due to its central role in the normal functioning of muscle cells and its implications in pathogenesis. The protein exhibits lipid phosphatase activity, which is essential for maintaining cellular membrane integrity and regulating phosphoinositide signaling, both of which are vital for muscle cell survival and function. Advanced studies have focused on the structure-function relationship of MTM1, with the hope of elucidating the molecular mechanisms underlying myotubular myopathy. Furthermore, understanding the interactions between MTM1 and other cellular components may reveal potential therapeutic targets for alleviating symptoms or correcting the underlying genetic defects. Given the complexity of muscle development and the emerging role of MTM1 in various cellular processes, ongoing research is essential to develop targeted gene therapies or small molecules that could restore normal function in affected individuals. The exploration of MTM1 not only enhances our comprehension of muscle biology but also provides insights into broader cellular pathways, positioning it as a significant focus within the fields of molecular biology and genetic medicine.
