Analytical Data
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基因名
RAB5C
- Application
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别名
RAB5C;RABL;Ras-related Protein Rab-5C
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51148
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表达区间
1-216aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMAGRGGAARPNGPAAGNKICQFKLVLL GESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDTTVKFEIWDT AGQERYHSLAPMYYRGAQAAIVVYDITNTDTFARAKNWVKELQRQASPNI VIALAGNKADLASKRAVEFQEAQAYADDNSLLFMETSAKTAMNVNEIFMA IAKKLPKNEPQNATGAPGRNRGVDLQENNPASRSQCCSN
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分子量
26 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAB5C is a member of the RAB family of small GTPases, which play crucial roles in intracellular membrane trafficking and endocytosis. The proper functioning of RAB5C is essential for regulating vesicle formation, fusion, and transport within the cell. Research has indicated that RAB5C is highly involved in various cellular processes, including the maturation of early endosomes and the recycling of membrane proteins. Abnormalities in RAB5C function have been linked to several diseases, including neurodegenerative disorders and cancer, where altered endosomal trafficking contributes to disease progression. The recombinant expression of RAB5C provides a valuable tool for studying its functional dynamics, interactions with other proteins, and the impact of mutations on its activity. By generating RAB5C recombinant protein, researchers aim to elucidate its role in cellular processes and its potential as a therapeutic target. Understanding the molecular mechanisms underlying RAB5C function will enhance our comprehension of cellular homeostasis and the pathological states arising from its dysregulation.
