Analytical Data
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Gene name
SLC39A7
- Application
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Alternative Names
SLC39A7；HKE4；RING5；Zinc transporter SLC39A7
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92504
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Expression Region
1-469aa
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AA Sequence
MARGLGAPHWVAVGLLTWATLGLLVAGLGGHDDLHDDLQEDFHGHSHRHSHEDFHHGHSHAHGHGHTHESIWHGHTHDHDHGHSHEDLHHGHSHGYSHESLYHRGHGHDHEHSHGGYGESGAPGIKQDLDAVTLWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQILLSFASGGLLGDAFLHLIPHALEPHSHHTLEQPGHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHVKGGHGHSHGHGHAHSHTRGSHGHGRQERSTKEKQSSEEEEKETRGVQKRRGGSTVPKDGPVRPQNAEEEKRGLDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEVPHEVGDFAILVQSGCSKKQAMRLQLLTAVGALAGTACALLTEGGAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLPELLREASPLQSLLEVLGLLGGVIMMVLIAHLE
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Molecular Weight
50.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC39A7, also known as ZIP7, is a member of the ZIP (Zinc-regulated transporter/iron-regulated transporter-like protein) family that plays a crucial role in maintaining cellular zinc homeostasis. Zinc is an essential trace element involved in numerous biological processes, including enzymatic reactions, gene expression, and cell signaling. Dysregulation of zinc transport can lead to various pathological conditions, including neurodegenerative diseases, cancer, and immune dysfunction. Research on SLC39A7 has gained momentum due to its implications in health and disease; for instance, studies have shown that altered expression of SLC39A7 affects zinc uptake and contributes to the progression of certain tumors. The recombinant protein of SLC39A7 is generated to facilitate in-depth studies of its functional properties, interactions with other cellular components, and its role in zinc transport mechanisms. Techniques such as protein expression in bacterial systems and purification methods are employed to produce functional SLC39A7 for biochemical assays. Understanding the characteristics and regulatory mechanisms of SLC39A7 provides insight into the broader context of zinc metabolism in human health and disease, highlighting its potential as a therapeutic target for disorders linked to zinc deficiency or dysregulation. This area of study is integral to expanding our knowledge of metal ion transporters and their significance in cellular physiology.
