Analytical Data
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基因名
P2RX1
- Application
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别名
P2RX1；P2X1；P2X purinoceptor 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P51575
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表达区间
1-399aa
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氨基酸序列
MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSGLISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEHPEGGICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLREAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESGQNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNLSPGFNFRFARHFVENGTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKYAEDMGPGAAERDLAATSSTLGLQENMRTS
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分子量
44.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
P2RX1, also known as the purinergic receptor P2X ion channel 1, is a member of the P2X receptor family, which plays a critical role in various physiological processes by mediating the effects of extracellular ATP. This receptor is widely expressed in several tissues, including the nervous system, the respiratory tract, and the immune system, where it is involved in pain perception, inflammation, and neuronal signaling. Research on P2RX1 has gained momentum due to its potential implications in various diseases, including chronic pain conditions, neurodegenerative disorders, and inflammatory diseases. The importance of investigating P2RX1 is underscored by its role as a therapeutic target; for instance, modulating its activity may provide novel strategies for pain management and inflammatory responses. Recent advancements in recombinant protein technology allow for the production of P2RX1 in a stable and functional form, enabling detailed studies of its biophysical properties, ligand-binding capabilities, and signaling mechanisms. Additionally, exploring the structure-function relationship of P2RX1 through crystallography and electrophysiological techniques can reveal insights into its gating mechanisms and potential pharmacological interventions. Overall, research on P2RX1 recombinant proteins is vital for understanding their biological functions and developing therapeutic approaches to treat a range of disorders associated with purinergic signaling.
