Cat: PA2000-9786

Recombinant Human NRM Protein,GST

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Analytical Data

  • 基因名

    NRM

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    NRM; NRM29; UNQ555/PRO1112; Nurim; Nuclear envelope membrane protein; Nuclear rim protein

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    GST-tag at N-terminal

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    Q8IXM6

  • 表达区间

    1-262  aa

  • 氨基酸序列

    MAPALLLIPAALASFILAFGTGVEFVRFTSLRPLLGGIPESGGPDARQGWLAALQDRSILAPLAWDLGLLLLFVGQHSLMAAERVKAWTSRYFGVLQRSLYVACTALALQLVMRYWEPIPKGPVLWEARAEPWATWVPLLCFVLHVISWLLIFSILLVFDYAELMGLKQVYYHVLGLGEPLALKSPRALRLFSHLRHPVCVELLTVLWVVPTLGTDRLLLAFLLTLYLGLAHGLDQQDLRYLRAQLQRKLHLLSRPQDGEAE

  • 分子量

    55.8 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

The study of NRM (Nuclear Receptor Modulators) recombinant proteins has gained significant interest in the field of molecular biology and pharmacology due to their essential role in regulating gene expression and cellular functions. NRM, a subclass of nuclear receptors, are pivotal in mediating the effects of various hormones, including steroid hormones, thyroid hormones, and retinoids. Their ability to act as transcription factors means that they influence numerous biological processes, including development, metabolism, and homeostasis. The recombinant production of NRM proteins provides valuable tools for understanding their structural characteristics, functional mechanisms, and interactions with ligands and co-regulators. Advances in recombinant DNA technology, including the use of bacterial, yeast, or mammalian expression systems, have facilitated the generation of functionally active NRM proteins. This allows researchers to investigate their roles in specific signaling pathways and disease contexts, notably in cancer and metabolic disorders. Furthermore, the elucidation of the 3D structures of these proteins through techniques like X-ray crystallography and cryo-electron microscopy has enhanced drug design efforts aimed at modulating their activity. Consequently, the ongoing research on NRM recombinant proteins not only contributes to the fundamental understanding of cellular regulation but also holds promise for the development of novel therapeutics targeting various diseases tied to nuclear receptor dysregulation.

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Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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