Analytical Data
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Gene name
NXNL1
- Application
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Alternative Names
NXNL1; TXNL6; Nucleoredoxin-like protein 1; Thioredoxin-like protein 6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96CM4
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Expression Region
1-212 aa
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AA Sequence
MASLFSGRIL IRNNSDQDEL DTEAEVSRRL ENRLVLLFFG AGACPQCQAF VPILKDFFVR LTDEFYVLRA AQLALVYVSQ DSTEEQQDLF LKDMPKKWLF LPFEDDLRRD LGRQFSVERL PAVVVLKPDG DVLTRDGADE IQRLGTACFA NWQEAAEVLD RNFQLPEDLE DQEPRSLTEC LRRHKYRVEK AARGGRDPGG GGGEEGGAGG LF
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Molecular Weight
23.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NXNL1 (Neural Retina Leucine Zipper Protein 1) is a gene that encodes a protein involved in various cellular processes, particularly in the retinal health and function of photoreceptors. It has garnered significant interest due to its potential role in retinal degenerative diseases, such as retinitis pigmentosa and age-related macular degeneration, conditions that result in vision loss. Research indicates that NXNL1 is crucial for maintaining the integrity of photoreceptor cells and protecting them from oxidative stress. Mutations in the NXNL1 gene have been associated with visual impairment, making it a target for therapeutic interventions. The study of NXNL1 recombinant proteins has been essential in elucidating its functional mechanisms and signaling pathways, paving the way for the development of gene therapies and protein replacement strategies. Recombinant NXNL1 proteins allow researchers to explore the interactions with other cellular components and assess their protective effects on retinal cells in vitro and in vivo. Additionally, understanding the structure and function of NXNL1 can lead to insights into its role in regulating gene expression and protein interactions in the retina, contributing to the overall understanding of retinal health and disease. As the field of gene therapy for retinal diseases advances, NXNL1 represents a promising candidate for future treatments aiming to restore or preserve vision in affected patients.
