Analytical Data
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基因名
SQSTM1
- Application
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别名
Sqstm1;A170;STAP;Sequestosome-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13501
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表达区间
1-440aa
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氨基酸序列
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSR VAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIK EKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDL CSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEM GPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSP LGIEVDIDVEHGGKRSRLTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNV EGATQSLAEQMRKIALESEGRPEEQMESDNCSGGDDDWTHLSSKEVDPST GELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPRLIESLSQ MLSMGFSDEGGWLTRLLQTKNYDIGAALDTIQYSKHPPPL
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分子量
74 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SQSTM1, also known as Sequestosome 1, is a multifunctional protein that plays a crucial role in cellular processes such as autophagy, the regulation of inflammation, and the maintenance of protein homeostasis. It serves as a scaffold for various signaling pathways, linking the ubiquitin-proteasome system with autophagy. The study of SQSTM1 has gained significant attention due to its association with several neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), where mutations in the SQSTM1 gene have been linked to disease onset and progression. As a key player in the cellular degradation pathways, SQSTM1's function is tightly regulated, and its dysregulation is implicated in the accumulation of misfolded proteins, thus contributing to neuronal toxicity. Research into SQSTM1 recombinant proteins aims to elucidate its structural and functional properties, providing insights into its role in disease mechanisms and potential therapeutic targets. By producing and analyzing SQSTM1 recombinants, scientists hope to better understand the protein's interactions and regulatory mechanisms, ultimately leading to improved strategies for modulating its function in the context of neurodegenerative diseases. This area of study not only advances the basic understanding of protein dynamics within cells but also opens new avenues for developing innovative treatments for related disorders.
