Analytical Data
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基因名
AP4m1
- Application
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别名
AP4m1；MUARP2；AP-4 complex subunit mu-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00189
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表达区间
1-453aa
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氨基酸序列
MISQFFILSS KGDPLIYKDF RGDSGGRDVA ELFYRKLTGL PGDESPVVMH HHGRHFIHIR HSGLYLVVTT SENVSPFSLL ELLSRLATLL GDYCGSLGEG TISRNVALVY ELLDEVLDYG YVQTTSTEML RNFIQTEAVV SKPFSLFDLS SVGLFGAETQ QSKVAPSSAA SRPVLSSRSD QSQKNEVFLD VVERLSVLIA SNGSLLKVDV QGEIRLKSFL PSGSEMRIGL TEEFCVGKSE LRGYGPGIRV DEVSFHSSVN LDEFESHRIL RLQPPQGELT VMRYQLSDDL PSPLPFRLFP SVQWDRGSGR LQVYLKLRCD LLSKSQALNV RLHLPLPRGV VSLSQELSSP EQKAELAEGA LRWDLPRVQG GSQLSGLFQM DVPGPPGPPS HGLSTSASPL GLGPASLSFE LPRHTCSGLQ VRFLRLAFRP CGNANPHKWV RHLSHSDAYV IRI
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分子量
49.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AP4M1 (adaptor protein complex 4 mu 1) is a crucial component of the adaptor protein complex responsible for intracellular transport, particularly within the endosomal-lysosomal pathway. This protein plays a significant role in clathrin-mediated endocytosis and is involved in the sorting and transport of various membrane proteins and lipids. Mutations or deficiencies in AP4M1 have been associated with neurological disorders, highlighting its importance in maintaining cellular function and integrity. Recent studies have focused on understanding the molecular mechanisms by which AP4M1 contributes to the trafficking of cargo proteins, as well as its potential implications in disease. Recombination techniques have allowed researchers to produce AP4M1 recombinant proteins, facilitating a deeper exploration of its structure and function. These studies aim to elucidate the interactions between AP4M1 and its partner proteins, providing insights into how disruptions in this system may lead to pathologies. Given the rising interest in the role of endosomal trafficking in various diseases, including neurodegenerative conditions, ongoing research on AP4M1 may pave the way for novel therapeutic approaches targeting these critical pathways. Understanding the nuances of AP4M1 interactions and functions could ultimately contribute to the development of strategies to mitigate the effects of its dysfunction in health and disease.
