Analytical Data
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Gene name
SYCE3
- Application
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Alternative Names
SYCE3；C22orf41；Synaptonemal complex central element Protein 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A1L190
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Expression Region
1-88aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MDDADPEERN YDNMLKMLSD LNKDLEKLLE EMEKISVQAT WMAYDMVVMR TNPTLAESMR RLEDAFVNCK EEMEKNWQEL LHETKQRL
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Molecular Weight
13 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SYCE3, a crucial protein involved in the formation of the synaptonemal complex during meiosis, has garnered significant attention in recent years due to its pivotal role in ensuring proper chromosome pairing and segregation. Meiosis is a specialized form of cell division that reduces chromosome number in gametes, and any disruption in this process can lead to infertility, aneuploidies, or developmental disorders. SYCE3 is known to interact with various other proteins in the synaptonemal complex, facilitating the structural organization necessary for homologous chromosome alignment. Studies have shown that mutations or aberrations in the SYCE3 gene can lead to compromised meiotic function and associated reproductive challenges. Consequently, research efforts have focused on the detailed characterization of SYCE3's structure, function, and interaction networks, employing techniques such as recombinant protein expression, molecular modeling, and biochemical assays. Understanding how SYCE3 operates within the meiotic pathway is vital for elucidating the underlying mechanisms of meiosis and could provide insights into potential therapeutic targets for infertility treatments and genetic disorders linked to chromosomal abnormalities. As such, the ongoing investigation into SYCE3's role is not only relevant for basic biology but also holds substantial implications for reproductive health and genetic research.
