Analytical Data
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Gene name
BCL6
- Application
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Alternative Names
BCL6；BCL5；B-cell lymphoma 6 Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P41182
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Expression Region
1-418aa
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AA Sequence
MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFIKASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAFAPSLYSGLSTPPASYSMYSHLPVSSLLFSDEEFRDVRMPVANPFPKERALPCDSARPVPGEYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYSVAEGLKPAAPSARNAPYFPCDKASKEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASGSPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPM
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Molecular Weight
59.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BCL6, a transcriptional repressor, plays a crucial role in regulating gene expression and is predominantly expressed in germinal center B cells. It is encoded by the BCL6 gene located on chromosome 3q27, which is frequently associated with various hematological malignancies, particularly diffuse large B-cell lymphoma (DLBCL). The protein functions by recruiting co-repressors and chromatin-modifying complexes, thereby silencing target genes involved in cell differentiation, apoptosis, and immune response. Dysregulation of BCL6, often due to chromosomal translocations or mutations, can lead to the aberrant activation of oncogenic pathways, contributing to tumorigenesis. Consequently, BCL6 has emerged as a pivotal therapeutic target in cancer research. Studies on BCL6 recombinant proteins focus on understanding its functional mechanisms, identifying potential inhibitors, and exploring its interactions within the cellular microenvironment. Additionally, the development of small molecules or monoclonal antibodies targeting BCL6 could provide novel strategies for treating BCL6-associated malignancies. Investigating BCL6 in the context of immune regulation and its impact on the tumor microenvironment is also critical, as it may reveal insights into immune evasion mechanisms utilized by tumors. Overall, research on BCL6 recombinant proteins not only enhances our comprehension of B cell biology and lymphomagenesis but also holds promise for innovative therapeutic approaches in oncology.
