Analytical Data
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Gene name
TPST2
- Application
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Alternative Names
TPST2；Protein-tyrosine sulfotransferase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60704
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Expression Region
26-377aa
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AA Sequence
ADPQQVLECRAVLAGLRSPRGAMRPEQEELVMVGTNHVEYRYGKAMPLIF VGGVPRSGTTLMRAMLDAHPEVRCGEETRIIPRVLAMRQAWSKSGREKLR LDEAGVTDEVLDAAMQAFILEVIAKHGEPARVLCNKDPFTLKSSVYLSRL FPNSKFLLMVRDGRASVHSMITRKVTIAGFDLSSYRDCLTKWNKAIEVMY AQCMEVGKEKCLPVYYEQLVLHPRRSLKLILDFLGIAWSDAVLHHEDLIG KPGGVSLSKIERSTDQVIKPVNLEALSKWTGHIPGDVVRDMAQIAPMLAQ LGYDPYANPPNYGNPDPFVINNTQRVLKGDYKTPANLKGYFQVNQNSTSS HLGSSHHHHHH
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Molecular Weight
40 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TPST2 (tyrosyl-protein sulfotransferase 2) is an integral enzyme involved in the post-translational modification of proteins through the sulfation of tyrosine residues. This process is critical for various biological functions, including cell signaling, receptor activation, and the modulation of protein interactions. Research on TPST2 has gained attention due to its role in various physiological and pathological processes, such as tumorigenesis and inflammation. Elevated levels of TPST2 have been associated with certain types of cancer, suggesting its potential as a biomarker and therapeutic target. The recombinant production of TPST2 allows for detailed studies of its enzymatic activity, substrate specificity, and regulatory mechanisms. Understanding the structure and function of TPST2 is essential for elucidating its role in cellular signaling pathways and developing novel strategies for cancer treatment and other diseases linked to sulfation abnormalities. Moreover, recombinant TPST2 can be utilized in biochemical assays to explore the effects of tyrosine sulfation on protein function, providing insights into the broader implications of this modification in health and disease. As research progresses, the ongoing characterization of TPST2 is expected to unravel new dimensions of its biological significance and therapeutic potential.
