Analytical Data
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Gene name
PALM2
- Application
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Alternative Names
PALM2Paralemmin-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IXS6
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Expression Region
1-376 aa
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AA Sequence
MEMAEAELHK ERLQAIAEKR KRQTEIEGKR QQLDEQILLL QHSKSKVLRE KWLLQGIPAG TAEEEEARRR QSEEDEFRVK QLEDNIQRLE QEIQTLESEE SQISAKEQII LEKLKETEKS FKDFQKGFSS TDGAVYAMEI NVEKDKQTGE TKILSTSTIG PEGVHQKGVK VYDDGTKVVY EVRSGGTVVE NGVHKLSTKD VEELIQKAGQ SSLGGGHVSE RTVIADGSLS HPKEHMLCKE AKLEMVHKSR KDHSSGNPGQ QAQAPSAAGP EANLDQPVTM IFMGYQNIED EEETKKVLGY DETIKAELVL IDEDDEKSLR EKTVTDVSTI DGNAAELVSG RPVSDTTEPS SPEGKEESLA TEPAPGTQKK KRCQCC
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Molecular Weight
122.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PALM2, a member of the PALM (Proteins Associated with Localization and Memory) family, has garnered considerable attention in the field of molecular biology due to its crucial role in cell signaling and memory processes. Research has highlighted its involvement in various cellular functions, including synaptic plasticity, which is essential for learning and memory in the brain. Studies have shown that dysregulation of PALM2 may be linked to neurodegenerative diseases and cognitive impairments, sparking interest in understanding its molecular mechanisms. The recombinant expression of PALM2 protein allows researchers to investigate its structure-function relationship and interactions with other cellular proteins. Moreover, the use of recombinant PALM2 offers opportunities for developing potential therapeutic strategies by targeting its pathways. Given the significance of PALM2 in neuronal health, the characterization of this protein through techniques such as crystallography and electron microscopy is critical for elucidating its role in neurobiology and its potential as a biomarker or therapeutic target. Overall, research on PALM2 emphasizes the need for a deeper understanding of its functions and the implications of its dysregulation in health and disease.
