Analytical Data
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Gene name
GFRA2
- Application
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Alternative Names
GFRA2；GDNFRB；GDNF family receptor alpha-2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00451-1
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Expression Region
1-441aa
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AA Sequence
MILANVFCLF FFLDETLRSL ASPSSLQGPE LHGWRPPVDC VRANELCAAE SNCSSRYRTL RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK KELQCLQIYW SIHLGLTEGE EFYEASPYEP VTSRLSDIFR LASIFSGTGA DPVVSAKSNH CLDAAKACNL NDNCKKLRSS YISICNREIS PTERCNRRKC HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS CSYEDKEKPN CLDLRGVCRT DHLCRSRLAD FHANCRASYQ TVTSCPADNY QACLGSYAGM IGFDMTPNYV DSSPTGIVVS PWCSCRGSGN MEEECEKFLR DFTENPCLRN AIQAFGNGTD VNVSPKGPSF QATQAPRVEK TPSLPDDLSD STSLGTSVIT TCTSVQEQGL KANNSKELSM CFTELTTNII PGSNKVIKPN S
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Molecular Weight
48 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GFRA2, or Glial Cell Line-Derived Neurotrophic Factor Family Receptor Alpha 2, is a member of the GDNF (Glial cell line-derived neurotrophic factor) receptor family, which plays a crucial role in the development and maintenance of the nervous system. The study of GFRA2 has gained significant interest due to its involvement in various cellular processes, including neuronal survival, growth, and differentiation. Research has shown that GFRA2 interacts with its ligand GDNF to activate signaling pathways that are essential for neuronal repair and regeneration, making it a potential target for therapeutic strategies in neurodegenerative diseases and injuries. Additionally, GFRA2 is implicated in various pathological conditions such as cancer, where it may influence tumor progression and metastasis. Understanding the structure and function of GFRA2 through recombinant protein studies allows for detailed investigations into its biological roles and mechanisms. This research not only provides insights into fundamental neurobiology but also holds promise for advancing treatment modalities for neurodegenerative disorders and cancer, highlighting the importance of GFRA2 in both health and disease.
