Analytical Data
-
基因名
BMPR2
- Application
-
别名
BMPR2；PPH1；Bone morphogenetic Protein receptor type-2
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q13873
-
表达区间
27-151aa
-
氨基酸序列
SQNQERLCAFKDPYQQDLGIGESRISHENGTILCSKGSTCYGLWEKSKGD INLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCSTDLCNVN FTENFPPPDTTPLSPPHSFNRDETIVDHHHHHH
-
分子量
15 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Bone morphogenetic protein receptor type 2 (BMPR2) is a crucial component of the bone morphogenetic protein (BMP) signaling pathway, which plays a significant role in regulating cellular growth, differentiation, and apoptosis. Mutations in the BMPR2 gene are linked to various pathologies, most notably pulmonary arterial hypertension (PAH), a severe condition characterized by high blood pressure in the pulmonary arteries, leading to heart failure and reduced exercise capacity. The degradation of BMPR2 signaling is a critical factor in the development of PAH, making it a target for therapeutic interventions. The study of recombinant BMPR2 protein serves multiple purposes: it helps in understanding the molecular mechanisms underlying receptor function and its role in disease, including elucidating the pathways affected by BMPR2 mutations. Additionally, recombinant BMPR2 can be employed in drug screening to identify potential compounds that could restore or enhance its function. Moreover, it provides a valuable tool for investigating protein-protein interactions and cellular responses to BMPs in various biological contexts. Research into recombinant BMPR2 is, therefore, pivotal not only for advancing our knowledge of BMP signaling but also for developing novel treatments for BMPR2-related diseases.
