Analytical Data
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Gene name
Cd300a
- Application
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Alternative Names
Cd300a；CMRF35H；CMRF35-like molecule 8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UGN4
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Expression Region
18-178aa
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AA Sequence
LSKCRTVAGPVGGSLSVQCPYEKEHRTLNKYWCRPPQIFLCDKIVETKGS AGKRNGRVSIRDSPANLSFTVTLENLTEEDAGTYWCGVDTPWLRDFHDPV VEVEVSVFPASTSMTPASITAAKTSTITTAFPPVSSTTLFAVGATHSASI QEETEEVVNSQVDDIEGRMDEPKSCDKTHTCPPCPAPELLGGPSVFLFPP KPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQ YNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPRE PQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTP PVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP GKHHHHHH
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Molecular Weight
45 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD300a, a member of the CD300 gene family, is an immune receptor primarily expressed on myeloid cells, including monocytes, macrophages, and dendritic cells. Its role in immune regulation has become a significant area of research due to its potential implications in various diseases, including autoimmune disorders, infections, and cancer. CD300a is known to interact with phosphatidylserine and other ligands, thereby influencing cell signaling pathways involved in immune responses. Recent studies have highlighted its ability to modulate the activation and differentiation of immune cells, suggesting that CD300a may serve as a critical regulator of immune homeostasis. The development of recombinant CD300a protein allows researchers to investigate its biological functions in detail and explore its potential as a therapeutic target. By studying this protein, scientists aim to elucidate the mechanisms underlying its immunoregulatory functions, which may lead to novel strategies for manipulating immune responses in various pathological contexts. Furthermore, understanding CD300a's signaling pathways could open new avenues for the design of interventions to enhance anti-tumor immunity or mitigate excessive inflammatory responses. Overall, research on recombinant CD300a protein represents a promising frontier in the field of immunology, with implications for advancing therapeutic approaches in immune-related diseases.
