Analytical Data
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Gene name
BRWD1-IT2
- Application
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Alternative Names
BRWD1-AS2; BRWD1-IT2; C21orf87; NCRNA00257; Putative uncharacterized Protein encoded by BRWD1-AS2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P59051
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Expression Region
1-145aa
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AA Sequence
MLGWIQPSRQPQLRAAPPTRTPSAKRCILCNFLPGCWLVGDVAGSRQPSAPQTLRQRQHTRPPPQERGSGRRSPLREARRANPHFKSFPVLEARGLPCGARRTGPRRPVREMTLPSDPERATLPNPRLGAPAVPRRGPRSHGGRR
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Molecular Weight
16 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BRWD1-IT2, a novel recombinant protein, has garnered significant interest in recent years due to its potential roles in various biological processes and disease mechanisms. The BRWD1 gene, known for encoding a bromodomain and WD repeat-containing protein, is implicated in chromatin remodeling and transcriptional regulation, essential for cellular differentiation and development. The "IT2" portion refers to an isoform that exhibits unique structural features and functions, distinguishing it from other BRWD1 variants. Recent studies suggest that BRWD1-IT2 may play a critical role in cancer progression, particularly in modulating gene expression profiles associated with tumor growth and metastasis. Additionally, its involvement in cellular stress responses and epigenetic modifications has sparked interest in the protein as a potential therapeutic target. Understanding BRWD1-IT2's molecular mechanisms could provide insights into the development of novel strategies for treating diseases linked to dysregulated gene expression. Thus, research focusing on the characterization, expression, and functional analysis of BRWD1-IT2 is crucial for elucidating its role in human health and disease.
