Analytical Data
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Gene name
BSCL2
- Application
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Alternative Names
BSCL2; Seipin; Bernardinelli-Seip congenital lipodystrophy type 2 Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96G97
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Expression Region
1-398aa
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AA Sequence
MVNDPPVPALLWAQEVGQVLAGRARRLLLQFGVLFCTILLLLWVSVFLYGSFYYSYMPTVSHLSPVHFYYRTDCDSSTTSLCSFPVANVSLTKGGRDRVLMYGQPYRVTLELELPESPVNQDLGMFLVTISCYTRGGRIISTSSRSVMLHYRSDLLQMLDTLVFSSLLLFGFAEQKQLLEVELYADYRENSYVPTTGAIIEIHSKRIQLYGAYLRIHAHFTGLRYLLYNFPMTCAFIGVASNFTFLSVIVLFSYMQWVWGGIWPRHRFSLQVNIRKRDNSRKEVQRRISAHQPGPEGQEESTPQSDVTEDGESPEDPSGTEGQLSEEEKPDQQPLSGEEELEPEASDGSGSWEDAALLTEANLPAPAPASASAPVLETLGSSEPAGGALRQRPTCSSS
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Molecular Weight
44 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BSCL2, or Bls2-associated protein 2, is a critical protein in lipid droplet (LD) formation and metabolism, closely associated with the regulation of cellular energy homeostasis. Mutations in the BSCL2 gene have been linked to severe metabolic disorders, particularly Berardinelli-Seip congenital lipodystrophy type 2, characterized by the near absence of adipose tissue, insulin resistance, and an increased risk of metabolic syndrome. The study of BSCL2 recombinant proteins offers insights into its structure and function, facilitating a deeper understanding of its role in lipid metabolism and cellular stress responses. Research on BSCL2 not only aims to elucidate the molecular mechanisms underlying lipodystrophy but also seeks to identify potential therapeutic targets for intervention in metabolic diseases. By employing recombinant protein techniques, researchers can analyze BSCL2 interactions with other cellular proteins and lipids, paving the way for innovative strategies to combat dyslipidemia and associated conditions. Given the rising prevalence of metabolic disorders globally, BSCL2 research holds significant promise for developing effective treatments and improving patient outcomes.
