Analytical Data
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基因名
EPHX2
- Application
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别名
EPHX2；Bifunctional epoxide hydrolase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P34913
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表达区间
1-555aa
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氨基酸序列
MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM
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分子量
78.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EPHX2 (epoxide hydrolase 2) is an enzyme that plays a crucial role in the metabolism of epoxides, which are reactive intermediates generated during the biotransformation of various xenobiotics and endogenous compounds. This enzyme is involved in detoxifying potentially harmful epoxide compounds, converting them into more water-soluble, less toxic diols. The significance of EPHX2 in drug metabolism and environmental toxicology has garnered increasing attention, as variations in its gene expression and activity can influence individual susceptibility to toxicants and the efficacy of certain pharmacological agents. Furthermore, EPHX2 has been implicated in various pathological conditions, including cancer and cardiovascular diseases, making it a target for therapeutic intervention. Recombinant EPHX2 protein has been developed to facilitate in-depth studies on its enzymatic mechanisms, substrate specificity, and potential role in disease processes. The use of recombinant technology allows for high yields and purification of the enzyme, enabling researchers to probe its functional properties under controlled conditions. Understanding the biochemical characteristics of EPHX2 could provide insights into its role in human health and disease, and pave the way for the development of biomarkers and targeted therapies. Therefore, ongoing research into EPHX2 recombinant protein contributes to a better understanding of its biological functions and potential applications in toxicology and medicine.
