Analytical Data
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Gene name
ENOX2
- Application
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Alternative Names
ENOX2；COVA1；Ecto-NOX disulfide-thiol exchanger 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q16206
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Expression Region
1-610aa
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AA Sequence
MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMA PLGIAGQPILPDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEI IHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVEVFEQ CGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRL HVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDH ECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHV RRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDH FTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETK ETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNK EQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLK EKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGIISTFLHVHPF GASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWK FCGFEGLKLT
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Molecular Weight
77 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ENOX2, a member of the enolase family, has gained significant attention in cancer research due to its unique expression patterns and potential role in tumorigenesis. Unlike the conventional enolases, ENOX2 is predominantly expressed in cancerous tissues while remaining largely undetectable in normal cells, making it a promising candidate for cancer biomarkers and therapeutic targets. Its involvement in the regulation of cellular metabolism and antioxidant defense mechanisms may contribute to the survival and proliferation of cancer cells under stressful conditions. Furthermore, ENOX2 has been implicated in immune evasion, suggesting that it may play a role in modulating the tumor microenvironment. Researchers are increasingly focusing on the recombinant production of ENOX2 protein to facilitate the detailed study of its structure and function, as well as to explore its potential applications in immunotherapy. The generation of ENOX2-based vaccines or targeted therapies could provide novel strategies for the treatment of various cancers, highlighting the importance of ongoing research into this enigmatic protein. As the understanding of ENOX2's biological roles expands, it holds promise not only as a diagnostic tool but also as a crucial player in the future of personalized cancer therapy.
