Analytical Data
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基因名
Pitx3
- Application
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别名
Pitx3；PTX3；Pituitary homeobox 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75364
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表达区间
1-302aa
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氨基酸序列
MEFGLLSEAE ARSPALSLSD AGTPHPQLPE HGCKGQEHSD SEKASASLPG GSPEDGSLKK KQRRQRTHFT SQQLQELEAT FQRNRYPDMS TREEIAVWTN LTEARVRVWF KNRRAKWRKR ERSQQAELCK GSFAAPLGGL VPPYEEVYPG YSYGNWPPKA LAPPLAAKTF PFAFNSVNVG PLASQPVFSP PSSIAASMVP SAAAAPGTVP GPGALQGLGG GPPGLAPAAV SSGAVSCPYA SAAAAAAAAA SSPYVYRDPC NSSLASLRLK AKQHASFSYP AVHGPPPAAN LSPCQYAVER PV
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分子量
31.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Pitx3, a member of the Pituitary homeobox (Pitx) gene family, plays a crucial role in the development and function of various tissues, particularly in the central nervous system and the eye. Its expression is largely confined to the midbrain, specifically in dopamine neurons, where it is essential for the survival and maintenance of these neurons. Research has shown that disruptions in Pitx3 function are implicated in neurodegenerative disorders, such as Parkinson's disease, highlighting its importance in neuronal health. Recombinant Pitx3 protein has emerged as a significant tool for studying its biological functions and molecular mechanisms. By producing and purifying this protein, researchers can investigate its roles in neuronal differentiation, gene expression regulation, and cellular signaling pathways. Moreover, understanding how Pitx3 interacts with other proteins and DNA can provide insights into its regulatory mechanisms and potential therapeutic targets. Given its involvement in neurodegeneration and developmental processes, recombinant Pitx3 protein holds promise for advancing basic biological research and developing treatments for neurodegenerative diseases, fostering a greater understanding of its role in neuronal health and disease pathology.
