Analytical Data
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基因名
MANSC1
- Application
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别名
MANSC1；LOH12CR3；MANSC domain-containing Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H8J5
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表达区间
1-431aa
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氨基酸序列
MFFGGEGSLTYTLVIICFLTLRLSASQNCLKKSLEDVVIDIQSSLSKGIRGNEPVYTSTQEDCINSCCSTKNISGDKACNLMIFDTRKTARQPNCYLFFCPNEEACPLKPAKGLMSYRIITDFPSLTRNLPSQELPQEDSLLHGQFSQAVTPLAHHHTDYSKPTDISWRDTLSQKFGSSDHLEKLFKMDEASAQLLAYKEKGHSQSSQFSSDQEIAHLLPENVSALPATVAVASPHTTSATPKPATLLPTNASVTPSGTSQPQLATTAPPVTTVTSQPPTTLISTVFTRAAATLQAMATTAVLTTTFQAPTDSKGSLETIPFTEISNLTLNTGNVYNPTALSMSNVESSTMNKTASWEGREASPGSSSQGSVPENQYGLPFEKWLLIGSLLFGVLFLVIGLVLLGRILSESLRRKRYSRLDYLINGIYVDI
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MANSC1 (Mannosyl-oligosaccharide-1,2-alpha-mannosidase) is a key enzyme involved in the glycosylation process, which plays a crucial role in protein folding, stability, and regulation in eukaryotic cells. The proper functioning of MANSC1 is essential for the maintenance of glycoprotein integrity, impacting various biological processes such as cellular communication, immune response, and tissue development. Abnormalities in mannosidase activity have been linked to several diseases, including congenital disorders of glycosylation and various cancers. Due to its significant role in glycoprotein metabolism, MANSC1 has emerged as a target for therapeutic intervention and as a potential biomarker for disease. Recent advances in recombinant protein technology have facilitated the production of functional MANSC1 in heterologous systems, enabling detailed studies of its biochemical properties and interactions. This research not only enhances our understanding of glycosylation pathways but also paves the way for the development of novel therapeutic strategies that could mitigate the effects of glycosylation-related disorders. As interest in personalized medicine and targeted therapies grows, the study of enzymes like MANSC1 is becoming increasingly relevant for advancing both the basic science of cellular biochemistry and the application of this knowledge in clinical settings.
