Analytical Data
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Gene name
RAET1L
- Application
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Alternative Names
RAET1L; ULBP6; UL16-binding protein 6; Retinoic acid early transcript 1L protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5VY80
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Expression Region
26-218 aa
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AA Sequence
RRDDP HSLCYDITVI PKFRPGPRWC AVQGQVDEKT FLHYDCGNKT VTPVSPLGKK LNVTMAWKAQ NPVLREVVDI LTEQLLDIQL ENYTPKEPLT LQARMSCEQK AEGHSSGSWQ FSIDGQTFLL FDSEKRMWTT VHPGARKMKE KWENDKDVAM SFHYISMGDC IGWLEDFLMG MDSTLEPSAG APLAMSSG
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Molecular Weight
27.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAET1L, a member of the RAET1 gene family, encodes a protein implicated in immune regulation, particularly in the context of the human immune response. It functions as a ligand for the NKG2D receptor, which is primarily expressed on natural killer (NK) cells and certain T cells. The interaction between RAET1L and NKG2D plays a crucial role in the activation of these immune cells, suggesting its potential involvement in tumor immunity and the body's response to viral infections. Given its significant role, researchers have been focused on understanding RAET1L's molecular mechanisms, including its expression patterns, regulatory pathways, and impact on immune system modulation. The production of recombinant RAET1L protein is vital for these studies as it allows scientists to investigate its functional properties and elucidate its role in immune responses further. Characterizing the structure and interactions of RAET1L could offer insights into therapeutic avenues for enhancing immune responses in cancer or autoimmunity, providing a foundation for innovative treatment strategies. As research progresses, RAET1L could emerge as a critical target for immunotherapy, highlighting the importance of understanding this protein in the broader context of immune dynamics and therapeutic development.
