Analytical Data
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基因名
RAPGEF2
- Application
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别名
CNrasGEF; Cyclic nucleotide ras GEF; KIAA0313; Neural RAP guanine nucleotide exchange protein; nRap GEP; NRAPGEP; PDZ domain containing guanine nucleotide exchange factor 1; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ GEF1; PDZ-GEF1; PDZGEF1; RA GEF; RA-GEF-1; Rap guanine nucleotide exchange factor 2; Rapgef2; Ras/Rap1-associating GEF-1; RPGF2_HUMAN
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y4G8
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表达区间
1398-1487 aa
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氨基酸序列
PITDFPEGHSHPARKPPDYNVALQRSRMVARSSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV
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分子量
35.64 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAPGEF2, a member of the Ras-activating protein family, plays a pivotal role in cellular signaling pathways, particularly in the modulation of Ras, a key regulator of cell proliferation, differentiation, and survival. Research has shown that RAPGEF2 interacts with small GTPases like Rap1, influencing various biological processes including cell adhesion, migration, and synaptic signaling. Its dysregulation has been implicated in several diseases, including cancer and neurodevelopmental disorders. Understanding the structure and function of RAPGEF2 at a molecular level is essential for deciphering its role in these pathways. Recombinant protein studies of RAPGEF2 aid in elucidating its biochemical properties, interaction mechanisms, and potential as a therapeutic target. By producing and analyzing recombinant RAPGEF2, researchers aim to uncover insights into its activity and regulatory roles within the cell, contributing to the development of novel strategies for disease intervention and treatment.
