Analytical Data
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基因名
RASSF4
- Application
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别名
RIN2; RASSF4; Ras and Rab interactor 2; Ras association domain family 4; Ras inhibitor JC265; Ras interaction/interference protein 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WYP3
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表达区间
1-321 aa
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氨基酸序列
MKEDCLPSSHVPISDSKSIQKSELLGLLKTYNCYHEGKSFQLRHREEEGTLIIEGLLNIAWGLRRPIRLQMQDDREQVHLPSTSWMPRRPSCPLKEPSPQNGNITAQGPSIQPVHKAESSTDSSGPLEEAEEAPQLMRTKSDASCMSQRRPKCRAPGEAQRIRRHRFSINGHFYNHKTSVFTPAYGSVTNVRVNSTMTTLQVLTLLLNKFRVEDGPSEFALYIVHESGERTKLKDCEYPLISRILHGPCEKIARIFLMEADLGVEVPHEVAQYIKFEMPVLDSFVEKLKEEEEREIIKLTMKFQALRLTMLQRLEQLVEAK
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分子量
61.05 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RASSF4, a member of the Ras association domain family, plays a significant role in various cellular processes, including cell proliferation, apoptosis, and tumorigenesis. Research into RASSF4 has gained momentum due to its potential involvement in cancer biology, particularly in the context of tumor suppression. The protein is known to interact with several signaling pathways, suggesting a regulatory role in cellular growth and survival. Initial studies have indicated that RASSF4 may serve as a critical player in the mitotic process and possess the ability to enhance the activation of apoptotic pathways, making it a candidate for exploration in therapeutic contexts. Given the frequent dysregulation of RASSF family members in various cancers, understanding the function and mechanisms of RASSF4 can provide valuable insights into tumorigenesis and highlight its potential as a biomarker or therapeutic target. Furthermore, the exploration of RASSF4's effects on cellular signaling cascades could unveil new strategies for cancer treatment and diagnosis. Consequently, the recombinant expression of RASSF4 in various model systems is essential for characterizing its biochemical properties, revealing its functional implications, and ultimately contributing to the development of targeted therapies in oncology. This research underscores the importance of RASSF4 in the broader landscape of cancer biology, emphasizing the need for further investigations to elucidate its precise mechanisms of action and potential implications in clinical settings.
