Analytical Data
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基因名
C9orf114
- Application
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别名
SPOUT1; C9orf114Putative methyltransferase C9orf114; EC 2.1.1.-; Centromere Protein 32; CENP-32; Kinetochore-associated Protein; SPOUT domain-containing methyltransferase 1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5T280
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表达区间
1-376aa
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氨基酸序列
MAERGRKRPCGPGEHGQRIEWRKWKQQKKEEKKKWKDLKLMKKLERQRAQEEQAKRLEEEEAAAEKEDRGRPYTLSVALPGSILDNAQSPELRTYLAGQIARACAIFCVDEIVVFDEEGQDAKTVEGEFRGVGKKGQACVQLARILQYLECPQYLRKAFFPKHQDLQFAGLLNPLDSPHHMRQDEESEFREGIVVDRPTRPGHGSFVNCGMKKEVKIDKNLEPGLRVTVRLNQQQHPDCKTYHGKVVSSQDPRTKAGLYWGYTVRLASCLSAVFAEAPFQDGYDLTIGTSERGSDVASAQLPNFRHALVVFGGLQGLEAGADADPNLEVAEPSVLFDLYVNTYPGQGSRTIRTEEAILISLAALQPGLIQAGARHT
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分子量
68.5 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C9orf114, also known as Chromosome 9 Open Reading Frame 114, is a gene that has garnered attention in the field of molecular biology and genetics due to its potential implications in various diseases. Recent studies have suggested that the protein encoded by C9orf114 may play a role in cellular processes such as gene expression regulation, cell differentiation, and immune responses. Its expression has been observed in various tissues, indicating a potential multifunctional role in vivo. Moreover, emerging evidence points towards its involvement in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), particularly in relation to the infamous hexanucleotide repeat expansion in C9orf72, which is located nearby. The creation and study of recombinant C9orf114 protein are crucial for understanding its structure and function, as well as its interaction with other proteins and cellular pathways. By utilizing recombinant DNA technology, researchers can produce this protein in a controlled environment, allowing for detailed biochemical assays and functional analyses. Understanding the biological function of C9orf114 and its potential pathophysiological roles could pave the way for novel therapeutic targets and strategies for disease intervention, thereby contributing significantly to the fields of neurobiology and genetics. As such, C9orf114 represents a promising area of investigation for both basic research and clinical applications.
