Analytical Data
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基因名
STXBP3
- Application
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别名
STXBP3；Syntaxin-binding Protein 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00186
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表达区间
1-592aa
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氨基酸序列
MAPPVAERGL KSVVWQKIKA TVFDDCKKEG EWKIMLLDEF TTKLLASCCK MTDLLEEGIT VVENIYKNRE PVRQMKALYF ITPTSKSVDC FLHDFASKSE NKYKAAYIYF TDFCPDNLFN KIKASCSKSI RRCKEINISF IPHESQVYTL DVPDAFYYCY SPDPGNAKGK DAIMETMADQ IVTVCATLDE NPGVRYKSKP LDNASKLAQL VEKKLEDYYK IDEKSLIKGK THSQLLIIDR GFDPVSTVLH ELTFQAMAYD LLPIENDTYK YKTDGKEKEA ILEEEDDLWV RIRHRHIAVV LEEIPKLMKE ISSTKKATEG KTSLSALTQL MKKMPHFRKQ ITKQVVHLNL AEDCMNKFKL NIEKLCKTEQ DLALGTDAEG QKVKDSMRVL LPVLLNKNHD NCDKIRAILL YIFSINGTTE ENLDRLIQNV KIENESDMIR NWSYLGVPIV PQSQQGKPLR KDRSAEETFQ LSRWTPFIKD IMEDAIDNRL DSKEWPYCSQ CPAVWNGSGA VSARQKPRAN YLEDRKNGSK LIVFVIGGIT YSEVRCAYEV SQAHKSCEVI IGSTHVLTPK KLLDDIKMLN KPKDKVSLIK DE
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
STXBP3, or Syntaxin Binding Protein 3, is a member of the Sec1/Munc18 (SM) protein family, playing a crucial role in vesicle trafficking and membrane fusion processes essential for neurotransmitter release. Research on STXBP3 has garnered interest due to its implications in neurological disorders, particularly its potential involvement in synaptic function and plasticity. Abnormalities in STXBP3 expression and function have been linked to conditions such as autism spectrum disorders and schizophrenia, highlighting its significance in the central nervous system. Studies have shown that STXBP3 interacts with various SNARE proteins, modulating the assembly of the SNARE complex necessary for exocytosis. Understanding the structure and function of recombinant STXBP3 protein is vital for elucidating its role in synaptic transmission. The production of recombinant STXBP3 enables in-depth biochemical and biophysical studies, facilitating the exploration of its interaction with other proteins and its participation in neurotransmitter release pathways. Investigating STXBP3 not only provides insights into fundamental cellular mechanisms but also suggests potential therapeutic targets for treating neurological diseases where synaptic dysfunction is a hallmark. Overall, the study of STXBP3 recombinant protein is crucial for advancing our understanding of synaptic biology and the molecular underpinnings of related disorders.
