Analytical Data
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基因名
SET7
- Application
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别名
FLJ21193; H3 K4 HMTase; H3-K4-HMTase SETD7; H4 lysine 4 specific; Histone H3 K4 methyltransferase; Histone H3 lysine 4 specific methyltransferase; Histone H3-K4 methyltransferase SETD7; Histone H4 K4 methyltransferase; Histone lysine N methyltransferase; Histone lysine N methyltransferase H3 lysine 4 specific SET7; Histone-lysine N-methyltransferase SETD7; KIAA1717; KMT7; Lysine methyltransferase; Lysine N-methyltransferase 7; OTTHUMP00000164543; OTTHUMP00000220049; SET 7; SET 7/9; SET 9; SET D7; SET domain containing (lysine methyltransferase) 7; SET domain containing protein 7; SET domain containing protein 8; SET domain-containing protein 7; SET7; SET7/9; SET9; Setd7; SETD7_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WTS6
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表达区间
110--366 aa
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氨基酸序列
YKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK
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分子量
48.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SET7, also known as SET7/9 or SET7/SET domain containing 7, is a histone methyltransferase that plays a crucial role in epigenetic regulation by catalyzing the monomethylation of lysine 4 on histone H3 (H3K4). This modification is associated with active transcription and is critical for processes such as gene expression, cell differentiation, and development. Research on SET7 has garnered attention due to its potential implications in various diseases, including cancer and neurodegenerative disorders, where altered epigenetic states contribute to pathological conditions. By regulating the transcriptional landscape, SET7 may influence several signaling pathways, including those involved in cell cycle progression and apoptosis. Given its importance in both normal physiology and disease states, SET7 has emerged as a promising target for therapeutic interventions. Moreover, understanding its structure and function can provide insights into the mechanisms underlying histone methylation and epigenetic regulation. Recent advancements in protein engineering and recombinant DNA technology have enabled the production of SET7 as a recombinant protein, facilitating in-depth studies of its enzymatic activity, substrate specificity, and interactions with other cellular factors. These studies hold the potential to unravel the complexities of epigenetic regulation and may lead to the development of novel epigenetic therapies aimed at restoring normal gene expression patterns in various diseases. Thus, SET7 not only serves as a pivotal molecule in epigenetics but also represents a key focus area in the search for effective treatment strategies against diverse pathological conditions.
